TMC-171A, B, C and TMC-154, Novel Polyketide Antibiotics Produced by Gliocledjum sp. TC 1304 and TC 1282.
نویسندگان
چکیده
منابع مشابه
TMC-89A and B, new proteasome inhibitors from streptomyces sp. TC 1087.
ubiquitin, and then degraded by a proteasome in an ATP dependent manner1^ The catalytic core of the proteasome is the 20S proteasome. New20S proteasome inhibitors would contribute to further understanding of the system2~4\ In the course of our screening program, wehave isolated several classes of 20S proteasome inhibitors including (i) the novel cyclic peptides, TMC-95s, and (ii) the new member...
متن کاملTMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.
New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in particular, cathepsin L wi...
متن کاملNew antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.
New antibiotics, phthoxazolins B, C and D were isolated from the fermentation broth of Streptomyces sp. KO-7888. They are geometrical isomers of 10-hydroxyphthoxazolin A. They showed selective antifungal activity against Phytophthora parasitica in vitro and modest herbicidal activity in a laboratory test, but the potencies were different among isomers.
متن کاملPyrronamycin A and B, novel antitumor antibiotics containing pyrrole-amide repeating unit, produced by Streptomyces sp.
topoisomerases, we have screened cultures of actinomycetes and fungi for their ability to inhibit selectively the growth of bacteriophage TP-68 at the concentration that shows no apparent antibacterial activity against NUB3620. In the course of microbial screening, strain KYI1768 was identified to produce active metabolites. We described here production including fermentation and isolation, and...
متن کاملSW-163A and B, novel immunosuppressants produced by Streptomyces sp.
SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed im...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1999
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.52.1114